Further studies are needed to understand if higher levels of IL-5 in the visceral fat of early-stage OGJ patients may have a positive or negative effect in the context of local and systemic anti-tumour immunity in the adipose tissue compartment and also in terms of how the systemic effects of higher levels of IL-5 in the adipose tissue may affect the distal tumour (Koyasu and Moro 2011). This evidence concerns the gene IL5 and neoplasm.