ACM derived from OGJ patients with early-stage tumours significantly increased the expression of CD27 on the surface of CD4+ T cells compared with untreated cells (untrx: 41.00 ± 3.5 vs. early-stage: 57.55 ± 5.0%, p = 0.01) (Fig. 1A). This evidence concerns the gene CD27 and neoplasm.