Therefore, this study aimed to investigate the effect of the visceral adipose tissue secretome from OGJ patients with both early- and late-stage tumours, on T cell phenotypes and whether addition of PD-1, PD-L1 or CTLA-4 ICBs might enhance an anti-tumour T cell phenotype (Pardoll 2012). The gene discussed is CTLA4; the disease is neoplasm.