ELN and Werner syndrome: SVAS is characterized by narrowing of the supravalvar aortic area, and is typically associated with WS, a congenital multisystem disorder involving the cardiovascular, connective tissue, and central nervous systems caused by a large 1.5–1.8 Mb deletion on chromosome 7q11.23 incorporating up to 27 different genes including ELN [2, 13–16].