GNAS and pancreatic intraductal papillary-mucinous neoplasm: Activating GNAS mutations are common in mucinous neoplasms such as intraductal papillary mucinous neoplasms (IPMNs) and low-grade appendiceal mucinous neoplasms (LAMNs), and several studies have shown that GNAS mutant CRCs often contain a mucinous component [14].