Intriguingly, loss of stoichiometry is found typically in p53 null cancers (Ajore et al., 2017), presumably because the checkpoints for free RPs that otherwise help impose stoichiometry (Zhang et al., 2003; Bursać et al., 2012; Oršolić et al., 2020; Lindström et al., 2022) are now inactivated. Here, TP53 is linked to cancer.