However, we note that as described above, mutations in Rpl10, including the T-ALL–associated Rpl10_R98S, impair the Lsg1-mediated release of Nmd3 (Sulima et al., 2014b; Patchett et al., 2017), which can be bypassed by additional mutations in Nmd3, which weaken its binding (Sulima et al., 2014b). Here, RPL10 is linked to acute lymphoblastic leukemia.