Moreover, the yeast QC suppressor mutant Enp1_R333E (Huang et al., 2020) is found analogously in cancer patients (BYSL-R303W or R303Q, The Cancer Genome Atlas [TCGA] www.cancer.gov/tcga, cBioPortal www.cbioportal.org; Fig. 3 C), supporting the notion that QC bypass occurs within cancer cells. Here, BYSL is linked to cancer.