RIOK1 and cancer: Interestingly, the homologous mutation to yeast T212N (PNO1_Y190N; Fig. 5 C) is found in cancer patient cells, akin to mutations in NOB1, PNO1, and RIOK1 (Fig. 5 C) that have the potential to disrupt the interactions between these proteins or with rRNA (TCGA www.cancer.gov/tcga, cBioPortal www.cbioportal.org), and are expected to act akin to Pno1_T121N or Pno1_KKKF.