The intense diuretic effect of the double KO Ncc/pendrin, also due of the ENaC and APQ2 inhibition associated to pendrin deletion and not associated to hypokalemia due to the considerable inhibition of ENaC, suggests that the combination of thiazide diuretics with a pendrin inhibitor could be very useful for patients with severe extracellular volume increase. This evidence concerns the gene SLC12A3 and Hypokalemia.