It was clearly observed that reduced NCC activity leads to hypocalciuria even when the calcium channel of the apical membrane of the DCT (TRPV5) is deleted, and therefore the reduction in urinary Ca2+ excretion is not due to the higher transcellular Ca2+ reabsorption in the distal tubules after inhibition of NCC (23). Here, SLC12A3 is linked to Hypocalciuria.