The Ncc gene (Slc12a3) is the target of mutations in Gitelman syndrome (19), a disease with late clinical manifestations and of varying intensity, which is characterized by hydroelectrolytic changes, such as hypokalemia, metabolic alkalosis, hypocalciuria, hypomagnesemia, and reduced extracellular volume with arterial hypotension. Here, SLC12A3 is linked to Gitelman syndrome.