Most impressively, NFATc1-expressing articular cartilage progenitors enrich a set of genes like Fbn2, Piezo2, Dchs1, Enpp1, Gdf6, Fgf9, Trps1, Col27a1, Tgfbr2, Col1a1, and Col1A2 [Figure 4(B)], whose mutations have been linked to a diverse range of human musculoskeletal disorders (https://www.omim.org). This evidence concerns the gene COL1A1 and musculoskeletal system disorder.