To assess whether Ranbp1 contributes to typical palate development, and if loss-of-function disrupts this key target of 22q11DS pathogenesis, we assessed the gross morphology of the developing palate in a cohort of E17.5 WT, Ranbp1+/− and non-exencephalic Ranbp1−/− embryos (Fig. 2A–D), and confirmed these findings by scanning electron microscopy of examples of key phenotypes (Supplementary Material, Fig. S2). This evidence concerns the gene RANBP1 and 22q11.2 deletion syndrome.