RANBP1 and microcephaly: We focused on Ranbp1 as a potential modulator of multiple 22q11DS morphogenetic phenotypes based upon its enhanced expression in neural crest and craniofacial primordia (9), its capacity to disrupt hindbrain patterning and cranial nerve differentiation (19), as well as its identity as a microcephaly gene based upon selectively disrupted neurogenesis in the cerebral cortex in Ranbp1−/− embryos (20).