Conflicting results have been obtained in studies investigating the diagnostic value of blood HGF level of patients with pancreatobiliary cancer.10-12 In a study evaluating the prognostic importance of the blood HGF level, it was determined that the blood HGF level in patients having pancreatic cancer was observed to have significantly higher levels in the advanced tumor stage, in the presence of lymph nodes and distant metastases, and it was stated that the blood HGF level could reflect the severity of the cancer.12 This evidence concerns the gene HGF and cancer.