The overexpression of c-MET protein has been demonstrated in tumor tissue in many types of cancer and it is associated with poor prognosis.6-9 Although there are studies indicating that c-MET overexpression in tumor tissue of patients with pancreatobiliary cancer is a prognostic biomarker, there is little information about the clinical significance of the blood HGF level of the patients. The gene discussed is MET; the disease is neoplasm.