For example, a cohort study of adult patients referred for nutritional assessment and adult patients with critical illnesses in Scotland showed that serum 25(OH)D concentrations were inversely related to CRP concentration [15], and a cross-sectional study of children with obesity in Spain also found an inverse correlation between 25(OH)D and CRP or IL-6 concentrations [16]. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.