If existing functional links between ER stress and regulation of lipid metabolism involving the SREBP‐SCAP‐INISG complex (Moncan et al, 2021) connect FGE stabilization and regulation of sterol and cholesterol pathway regulation, both induced by tazarotene treatment in MSD cells, need to be elucidated by future experiments. The gene discussed is SCAP; the disease is Multiple sulfatase deficiency.