LYST and Hermansky-Pudlak syndrome: For example, in human, mutations in TYR, OCA2, TYRP1, SLC24A5 or SLC45A2 lead to oculocutaneous albinism, and mutations in genes related to cellular functions have been identified as responsible for causing ocular albinism (GPR143, GNAI3), Hermansky-Pudlak syndrome (BLOC1-3, AP-3) or Chediak-Higashi syndrome (LYST, CHS1) [25,26].