For instance, nuclear and cytoplasmic RBM45 inclusions were reported in neurons and glia of ALS disease, TDP-43 associated frontotemporal lobar degeneration and Alzheimer’s disease.30 RBM45 is involved in RNA splicing and spliceosome functions; however, the precise function is not clearly understood. The gene discussed is RBM45; the disease is early-onset autosomal dominant Alzheimer disease.