VCP and amyotrophic lateral sclerosis: VCP mediates ubiquitin-dependent protein extraction from chromatin through the ubiquitin–proteasome system.2 Inactivation of VCP leads to protein-induced chromatin stress and aggregation, which has been studied in the context of DNA repair and replication.2 Our data provide a model to understand how VCP mutations affect transcriptional machinery in an ALS model system.