YTHDF1 and amyotrophic lateral sclerosis: It has been reported that RNF220 heterozygote mutant mice develop ALS pathology.36 GIGYF2 is an RBP, and heterozygous Gigyf2+/− mice develop adult-onset neurodegeneration.37 YTHDF1 is a reader of m6A-modified mRNAs and is required for axon regeneration in neurons.38