The pooled incidence of severe hypoglycemia (defined by an event during which the patient requires the assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions) was reported among 5 studies [14, 16, 19, 21, 22] for placebo, and 7 studies [14, 16, 21-25] for different doses of tirzepatide. The gene discussed is GCG; the disease is Hypoglycemia.