Western blot analysis of the intracranial U87ΔEGFR tumor-bearing mice brain tissues revealed significant down-regulation of the RAGE signaling pathway in OVesRAGE-treated tumors compared with control rHSVQ-treated tumors, as evidenced by decreased pMEK1/2 and pErk and increased cleaved PARP (Figure 6B). Here, AGER is linked to neoplasm.