We found that major pathology response (MPR), pathological tumor, node, and metastasis stage post‐NCT (ypTNM), post‐chemotherapy TIL, post‐chemotherapy CD8+TIL, naïve CD4+TIL, naïve CD4+/CD8+TIL ratio, and change of CD4+TIL are prognostic factors of NCT‐NSCLC. This evidence concerns the gene CD4 and neoplasm.