PRKCA and heart failure: α‐Tocopherol promotes barrier function and anti‐inflammatory responses by binding to the regulatory domains of protein kinase Cα (PKCα), a regulator and antagonist of heart failure, and decreases the activation of the pro‐inflammatory transcription factor NF‐κB, which results in cytokines and mast cell activation (Cordero et al., 2018; Tettamanti et al., 2018).