Besides, SIRT1–endothelial nitric oxide synthase (eNOS) axis (Ota et al., 2010), oxidative stress (OS), malondialdehyde (MDA), lipid profile, as well as total antioxidant capacity (TAC) and superoxide dismutase (SOD) (Puca et al., 2013) are among the indices of endothelial–vascular function impairment due to aging and diabetes (Assar et al., 2016). The gene discussed is NOS3; the disease is diabetes mellitus.