The present study aimed to reflect on the impact of 8 weeks of a combination of UA supplementation and resistance/endurance training in old male Wistar rats having a high‐fat diet and/or low‐dose streptozotocin‐induced type 2 diabetes (HFD/STZ‐induced T2D), with an emphasis on Sirtuin 1 (SIRT1)–endothelial nitric oxide synthase (eNOS) axis and OS indices in their aortic tissues. The gene discussed is SIRT1; the disease is type 2 diabetes mellitus.