The sex hormone, estrogen, can result in the hypomotility of the gallbladder, enhance hepatic lipoprotein uptake, inhibit its catabolism to bile salts, reduce bile salt secretion, and promote hepatic secretion of cholesterol into the gallbladder, thus causing cholesterol supersaturation in bile and explaining why more women than men have GSD in occidental areas. This evidence concerns the gene PLXNA3 and disorder of glycogen metabolism.