In particular, it is highly associated with both viral infection and prion diseases in the brain [61,62].miR-146a has been shown to suppress rho-associated, coiled-coil-containing protein kinase 1 (ROCK1), which results in hyperphosphorylation of Tau in association with Alzheimer's disease [63]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.