PRNP and prion disease: In contrast, the Pfizer version has the potential to produce nine, and the Moderna version can form 19 [132].The author of a paper published in 2014, aptly titled "G-quadruplexes within prion mRNA: the missing link in prion disease?" wrote the following in the conclusion: "The presence of G4 forming motifs in PrP mRNA may provide the missing link in the initial conversion of PrPC to PrPSC.