The relationship between IL-10 levels detected in our results and clinical severity is similar to that seen in Saksida et al. In addition, Perez et al. conducted a prospective study on 28 patients with diagnosed dengue hemorrhagic fever to examine the levels of IL-12, IL-10, and RANTES (regulated on activation, normal T-cell expressed and secreted). IL-10 levels have been shown to be a strong inflammatory marker of thrombocytopenia and vascular damage [27]. This evidence concerns the gene IL10 and Dengue hemorrhagic fever.