Patients with pSS who had drug allergy had significantly more food allergy (19.5%) and higher levels of eosinophils (159.5/μL) than those without drug allergy (9.3% and 97.4/μL), and a numerically higher positivity rate of anti-SSA antibody (89.6% vs. 79.7%; P = 0.056) than those without drug allergy. Here, TRIM21 is linked to drug allergy.