Characteristically, the formation of demyelinating lesions in the central nervous system is associated with immunosenescence in MS.[30,31] Currently, immunosenescence might be involved in MS where some features of immunosenescence were observed, like the accumulation of CD4+ CD28− T cells.[30,32] Yet, there are few studies of the aging-associated mechanisms in MS, especially for ABCs. This evidence concerns the gene CD28 and myeloid sarcoma.