In contrast to CD4 T cells, the frequency of GZMK+GZMB− CD8 T cells was significantly lower in MDA5+DM patients than that in HDs (HDs vs. MDA5+DM: 6.53 ± 5.92% vs. 1.63 ± 1.13%, P = 0.0038) (Figure 3B). This evidence concerns the gene CD8A and dermatomyositis.