DOK3 and rheumatic disorder: Recently, our laboratory has identified Dok3 to be a key negative regulator of neutrophilic effector mechanisms, and it functions in a context-dependent manner downstream of different immunoreceptors via interaction with a distinct set of signal transducing molecules.[45,46,47] Thus, it is tempting to speculate that Dok3 may regulate neutrophil responses during rheumatic diseases as well.