TP53 and differentiated thyroid carcinoma: aThe presence either suggests an associated thyroid tumor or rules out NIFTP.; b Follicular pattern, no papillae, no psammomatous calcifications, no florid nuclear features of papillary thyroid carcinoma, no necrosis or mitoses; c When a nodule has BRAFV600E or other BRAFV600E-like mutations (e.g., RET/PTC fusions), high-risk mutations, such as TERT promoter, p53, NIFTP is essentially ruled out.