Moreover, the increased expression of ACE2 and ACE1 in type1 and type2 diabetes, high blood pressure, and hypertension is often treated with ACE inhibitors and angiotensin II type-I receptor blockers (Tseng, Yang & Lu, 2020; Guan et al., 2020; Zhang et al., 2020). The gene discussed is ACE; the disease is hypertensive disorder.