Obesity imposes a particular condition and the release of adiponectin, a molecule with pro-inflammatory properties, in contrast to the increased production and release of leptin and resistin, which involves the production and two reactions, by the lesser role of adipose tissue, improving and accentuating the manifestation of low-grade chronic inflammation associated with obesity and MS [7]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.