TNF and obesity due to melanocortin 4 receptor deficiency: Therefore, to understand the benefit of bariatric surgery by RYGB in women with severe obesity and MS, whose inflammatory profile (adiponectin, resistin, leptin, TNF-α, IL-1β, IL-6, IL-17, and IL-23) is available, an improvement in the understanding and description of the changes in the group of parameters before and after the surgery in this population is extremely important for clinical practice.