The main objective of this study was to verify the effects of weight loss induced by RYGB on the circulating levels of systemic inflammatory markers adiponectin, resistin, leptin, TNF-alpha, IL1-beta interleukins, IL-6, IL-8, IL-17, IL-23 and IGF-1 in women with severe obesity and MS. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.