NPTX2 and Alzheimer disease: Importantly, these results are somehow in agreement with those found by Goetzl et al., who identified four proteins of neuronal origin (GluA4-containing glutamate receptor, neuronal pentraxin 2, neurogranin, and neurexin 2α) that were significantly decreased in the neuronal-derived pEVs of AD patients compared to those of healthy controls [50].