In our study of the interaction between cancer cells and stromal cells, such as those residing in the bone marrow microenvironment, we found that plastic-adherent primary human MSCs growing on fibronectin (5 μg/cm2)-coated glass coverslips for 24 h produce a new type of cellular bulges, called migrasomes, along the retraction fiber network (Fig. 1A). This evidence concerns the gene FN1 and cancer.