The heatmap of Fig. 4A showed representative transcripts where differential methylation loci (DML) located in lung tissues between IUGR d1 and control d1 groups, indicating increased ET1 (Edn1) expression and decreased A20 (Tnfaip3) expression in newborn IUGR rats. The gene discussed is TNFAIP3; the disease is fetal growth restriction.