ST8SIA6 and colorectal cancer: Another axis of regulation was represented by GATA1/2/3 and TAL1: Whilst this set of TFs generally correlated negatively with FUT7 expression, significant positive associations were found for several sialyltransferases, e.g., ST3GAL2, ST6GALNAC1/4/6, and ST8SIA6. In addition to the generally immune dampening functions of extensive sialylation via SIGLECs [51, 52], ST8SIA6-dependent α-2,8 sialylation has been recently identified as a potent immunomodulator promoting tumor growth in colorectal cancer and melanoma cell lines [66].