Regarding increasing of ESRα /β ratio [60] as well as overexpression of HDAC2 [46, 61, 62] that have been reported in several tumor cells, such as ovarian cancer, our data make us more cautious in the long-lasting exposure to the high concentrations of complex phytoestrogens in the combination of these two plants. The gene discussed is HDAC2; the disease is ovarian cancer.