SNCA and Parkinson disease: However, it is worth pointing out that deletion of TLR2 did not diminish the deposition of p-α-synuclein, indicating that the process by which α-synuclein was phosphorylated occurs at least partially upstream of TLR2 signaling and that a single anti-inflammatory therapy may not address a substantial amount of underlying pathology or prevent the development of PD [67].