In a previous study showing that the removal of p16Ink4a-positive cells prevented glomerulosclerosis, a renal aging phenotype, and attenuated the decline in renal function, SA-β-Gal-positive cells were present in tubular epithelial cells, suggesting that the removal of senescent cells in tubular epithelial cells may prevent renal aging [6]. The gene discussed is CDKN2A; the disease is glomerulosclerosis.