In summary, our study demonstrated that activation of IL-6/STAT3/SAA signaling by hepatocyte SGK1 in response to IR promotes the formation of a pre-metastatic niche in the liver of CRC, and that tumor-associated NETs and PMN-MDSCs participate in the formation of CRC in an SGK1-dependent manner. This evidence concerns the gene STAT3 and colorectal carcinoma.