SHBG and acne: Many of the systems in the body are affected by PCOS which leads to several complications such as menstrual disorders, infertility, hirsutism, acne, obesity and metabolic syndrome [8], increase in LH levels, slight decrease or lack of change in FSH levels, a slight increase in prolactin, increase in estradiol and estrogen levels, possible increase in dehydroepiandrosterone sulfate (DHEAS), androstenedione, and testosterone, and decrease in sex hormone-binding globulin (SHBG) levels [9].