INS and Insulin resistance: A 2009 prospective study in Denmark to determine the association between insulin sensitivity and insulin secretion with the development of normoglycemic individuals to IFG or IGT reported that liver insulin resistance and subsequent dysfunction of beta cells in the secretion of insulin are the main factors in the progression of normal blood glucose to iIFG during 5 years, while the reduction of whole-body sensitivity and consequently insulin secretion dysfunction was reported as the major factors leading to iIGT [21].