In the present study, daily supplementation of aqueous and ethanolic R. ribes extract for 6 weeks was led to significant changes in insulin, HOMA-B, HOMA-IR, ApoB and ApoB/ApoA1 ratio in patients with T2DM compared to control group, but serum levels of ApoA1 was not significantly increased in these groups compare to control group. Here, APOA1 is linked to type 2 diabetes mellitus.