INS and type 2 diabetes mellitus: In the present study, daily supplementation of aqueous and ethanolic R. ribes extract for 6 weeks was led to significant changes in insulin, HOMA-B, HOMA-IR, ApoB and ApoB/ApoA1 ratio in patients with T2DM compared to control group, but serum levels of ApoA1 was not significantly increased in these groups compare to control group.