Adenoviral vector has been used to deliver VEGF121 to BPH/5 mice via tail vein and the authors confirmed that adenoviral-mediated delivery of VEGF121 upregulated the plasma-free VEGF level, accompanied by restored angiogenic ability, reduced fetal resorptions and prevented hypertension and proteinuria at the late gestation [29]. This evidence concerns the gene VEGFA and benign prostatic hyperplasia.