Thus, this study aimed to evaluate the clinical efficacy of tacrolimus 0.1% in mucoadhesive patches compared to tacrolimus or corticosteroids in gel form for symptomatic oral lichen planus and to investigate the effect of these medications on the expression of caspase 3 in oral lichen planus lesions as an early marker of apoptosis. This evidence concerns the gene CASP3 and oral lichen planus.