HSPA5 mRNA expression levels were shown previously to be elevated in placentas with preeclampsia.56 Moreover, HSPA5 mRNA expression was higher in fetal membranes from SPTBs with ongoing infection.57 In our current study, HSPA5 mRNA expression as measured by qPCR was not increased in SPTB placentas. The gene discussed is HSPA5; the disease is infection.