Mounting evidence has confirmed that p53 is involved in a range of cellular metabolic processes, including aerobic glycolysis, OXPHOS, and antioxidant response, besides its pro-apoptotic function during DNA damage.34 Typically, the p53 SNP at codon 72 has been implied to determine mitochondrial function in tumor cells, although the underlying mechanism remains unclear.11 Here, we screened the discrepant interactome of p53 codon 72 variants and identified PSAT1 as a p5372P-interacting protein. Here, TP53 is linked to neoplasm.