PSAT1 and neoplasm: Previous studies have indicated the critical role of serine in regulating cell proliferation, and inhibition of endogenous serine synthesis through interfering phosphoglycerate dehydrogenase (PHGDH) or PSAT1 may enhance the anti-tumor effect of extrinsic serine restriction.36,37 However, complete dietary inhibition of serine seems difficult and the effect of serine on tumor metastasis remains largely unclear.