PPARGC1A and neoplasm: Indeed, the p5372P variant has been revealed to bind to PGC-1α, which decreased the level of genes transcribed by PGC-1α.11 In the present study, we found that PSAT1 was pivotal in the metabolic switch of tumor cells harboring the 72P variant of p53, and the interaction of PSAT1 and p5372P variant was essential for maintaining the activity of PGC-1α.