PSAT1 and liver cancer: Moreover, PSAT1 knockout or knockdown significantly impaired the migration of liver cancer cells (PLC/PRF/5) and CRC cells (HT29) expressing p5372P variants (Fig. 3c, d and Supplementary Fig. S2c), while overexpression of PSAT1 promoted the migration and invasion of HepG2 cells containing p5372P variants (Supplementary Fig. S2d–f).