Interestingly, we found that p53-72Pro showed a specific interaction with phosphoserine aminotransferase 1 (PSAT1), which acted to promote the mitochondrial function and metastatic potential of tumor cells expressing p53-72Pro by facilitating the nuclear translocation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). The gene discussed is PPARGC1A; the disease is neoplasm.