We found that 25.0% intestine- and 37.8% esophagus-specific proteins, such as ELF3 and EPHA2, respectively, were upregulated in the tumor tissues, whereas 77.1% stomach-specific proteins, such as MUC5AC, were downregulated (Supplementary Fig. 2e, Supplementary Data 3d). This evidence concerns the gene MUC5AC and neoplasm.