Among them, 1548 proteins, 123 TFs, and 163 phospho-sites were upregulated, and 671 proteins, 20 TFs, and 194 phospho-sites were downregulated (two-sided Wilcoxon signed-rank test, BH adjusted p < 0.05, ratio of tumor to NAT (T/NAT) > 2 or <0.5, Fig. 1b, Supplementary Data 3a–c) in tumor tissues. The gene discussed is BRD2; the disease is neoplasm.