Therefore, we explored for the first time the mechanism that SLP-2 deficiency can mediate myocardial fibrosis and adverse cardiac remodeling by regulating the PI3K-Akt-mTOR signaling pathway to enhance autophagy, which will play a vital role in alleviating myocardial fibrosis, cardiac remodeling and improving the prognosis of patients with end-stage heart disease. Here, AKT1 is linked to Myocardial fibrosis.