Interestingly, many of the up-regulated genes are involved in mental conditions and higher cognitive functions, including the schizophrenia- and autism-associated gene SYN2 and cognition- and intelligence-associated genes FMN2, CTNND2, and CACNA1A (Supplementary Fig. S9g)67–71. The gene discussed is CACNA1A; the disease is schizophrenia.