BIRC2 and neoplasm: As BRD7 has been identified as a tumor suppressor that inhibits cell proliferation and tumor growth, which was also confirmed with overexpression and knockdown of BRD7 by CCK-8 and colony formation assays (Fig. S3A, B), while BIRC2 could be negatively regulated by BRD7 and function as an oncogene in NPC, we sought to further ascertain the exact effect of BIRC2 on BRD7-mediated proliferation inhibition in nasopharyngeal carcinoma cells.