CACNA1D and major depressive disorder: Selective inhibition of hyperactive Cav1.3 signalling therefore appears as a potential treatment not only for the treatment of disorders with rare CACNA1D variants, but also for more frequent neuropsychiatric disorders, such as autism spectrum disorders or depression (Cav1.3‐deficient mice display reduced depression‐like behaviours, Sinnegger‐Brauns et al., 2004a).