BCR and primary central nervous system lymphoma: The mutation profile of MCD/C5/MYD88, including mutations in the BCR, Toll like receptor (TLR) and NFKB pathways as well as immune evading mutations is highly reminiscent of those reported in extranodal lymphomas such as primary central nervous system lymphomas (PCNSL) and testicular lymphomas (PTL) 46–49.