GFAP and Alzheimer disease: However, a link between pathological tau (usuallyviewed as a later pathological event in the AD continuum) and EAAT2was demonstrated in temporal cortex homogenates from AD brains.105 Specifically, EAAT2 was shown to interact withhyperphosphorylated tau rather than nonpathological tau.105 In a transgenic mouse model of astrocytic taupathology (GFAP/tau Tg mice), decreased EAAT2 levels were evidentthroughout the spinal cord and reflected on motor impairment in theseanimals.