SOD1 and amyotrophic lateral sclerosis: Then, CTE is SUMOylated (CTE-SUMO-1) and accumulates in thespinal cord of SOD-1 mice.72 CTE-SUMO-1accumulation was mostly seen in the presymptomatic stage and specificmouse brain regions related to ALS.72 Inagreement with these findings, a mutation on the EAAT2 site for caspase-3cleavage extended mice life span and delayed the progression of motorchanges.73