SLC1A2 and Alzheimer disease: To further explorethe efficacy of these pyridazine-based compounds, in a mixed cultureof astrocytes and neurons, compound 11 (LDN/OSU-0212320)prevented glutamate excitotoxicity by selective increase on EAAT2expression.137 In keeping with this, translationalactivators of EAAT2 may have a potential therapeutic application inneurodegenerative diseases in which EAAT2 damage occurs mostly atthe posttranslational level, such as AD.88,138 Loss of EAAT2 protein in APPSw,Ind mice is caused bydisturbances at the post-transcriptional level because EAAT2 mRNAis not decreased.