PSEN1 and Alzheimer disease: However, it is important to emphasizethat rodent models such as APP/PS1 (mice containing human transgenesfor APP Swedish mutation and PSEN1 containing an L166P mutation)92 or 5xFAD (mice containing 5 human AD-linkedmutations) do not reflect the complexity of AD pathogenesis, but rathermimic amyloidosis in AD.