The beta-lactam antibiotic ceftriaxone increases EAAT2 expressionat the transcriptional level through NF-κB-mediated EAAT2 promoteractivation and restored EAAT2 function in animal models of ALS, AD,and PD by delaying loss of neurons and muscle strength, improvingcognitive performance, and increasing survival.96,122−125 The clinical efficacy of ceftriaxone was tested so far in ALS,126,127 and PD (on going, NCT03413384). This evidence concerns the gene SLC1A2 and Alzheimer disease.