We overexpressed lncRNA H19 in HF-MSCs and harvested the exosomes, OE-H19-Exo, which were found to enhance HaCaT proliferation, migration, and inhibit apoptosis following high expression of the inflammation factor NLRP3, caspase-1, ILβ, and IL18 in the model of the injury cell model. The gene discussed is H19; the disease is hydrops fetalis.