MSCs secreted exosomes (MSCs-Exo) have been demonstrated to have protective effects against liver fibrosis in vivo and also modify epithelial to mesenchymal transition (EMT) markers by elevating the count of E-cadherin-positive cells while decreasing the count of N-cadherin- and vimentin-positive following MSCs-Ex transplantation in mice [33, 34]. This evidence concerns the gene VIM and Hepatic fibrosis.